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American Society of Microbiology ABMM Sample Questions:
1. A clinical laboratory performs a cefoxitin disk diffusion test on a Staphylococcus aureus isolate from a wound culture. The zone of inhibition measures 18 mm. According to current CLSI M100 guidelines, how should this result be interpreted regarding oxacillin/methicillin susceptibility?
A) Resistant (report oxacillin as resistant; infer MRSA)
B) Intermediate (requires MIC testing)
C) Indeterminate (requires mecA gene testing)
D) Susceptible (report oxacillin as susceptible)
2. A patient develops severe, watery diarrhea shortly after starting a course of clindamycin. Stool testing using a cytotoxicity assay is positive. This result is most consistent with infection by which organism?
A) Campylobacter jejuni
B) Clostridioides difficile
C) Norovirus
D) Giardia lamblia
3. A patient with a history of heart valve replacement develops subacute bacterial endocarditis. Blood cultures grow a Gram-positive coccus that is alpha-hemolytic on blood agar, catalase-negative, and optochin-resistant.
The MOST likely organism is:
A) Viridans streptococci
B) Streptococcus pneumoniae
C) Streptococcus pyogenes
D) Enterococcus faecalis
4. A clinical microbiology laboratory is performing antimicrobial susceptibility testing using the broth microdilution method. The minimum bactericidal concentration (MBC) is determined by:
A) Comparing the zone of inhibition around antibiotic disks to standardized tables.
B) The highest concentration of antibiotic that allows visible growth after 24 hours of incubation.
C) Subculturing the clear wells from the MIC assay onto antibiotic-free media and determining the lowest concentration that results in no bacterial growth.
D) The lowest concentration of antibiotic that inhibits visible growth after 24 hours of incubation.
5. A patient develops a severe gastrointestinal illness after consuming undercooked poultry. Stool culture yields a Gram-negative, microaerophilic, curved bacillus that is oxidase-positive. The MOST likely organism is:
A) Campylobacter jejuni
B) Shigella dysenteriae
C) Yersinia enterocolitica
D) Salmonella enterica
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: B | Question # 3 Answer: A | Question # 4 Answer: C | Question # 5 Answer: A |
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